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CHAPTER 1
CHAPTER 2
CHAPTER 3
CHAPTER 4
CHAPTER 5
CHAPTER 6
CHAPTER 7
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CHAPTER 9
CHAPTER 10
CHAPTER 11
CHAPTER 12
CHAPTER 13
CHAPTER 14
CHAPTER 15
CHAPTER 16
CHAPTER 17
CHAPTER 18
CHAPTER 19
CHAPTER 20
CHAPTER 21

In vitro antifungal susceptibility of nondermatophytic keratinophilic fungi

Josep Guarro1, Isabel Pujol2, Carmen Aguilar1 and Montserrat Ortoneda1

1Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili and
2Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus, Reus, Tarragona, Spain
Nondermatophytic keratinophilic fungi like Scytalidium spp. and Chrysosporium spp. have been associated with superficial skin infections in humans. However, there have also been reports of more severe infections both localized and disseminated caused by these fungi. The best way to treat such infections has not yet been defined. We have evaluated the in vitro activity of amphotericin B, flucytosine, fluconazole, ketoconazole, miconazole and itraconazole against 29 strains of representative species of these two genera (17 strains of Scytalidium spp. and 12 strains of Chrysosporium spp.), by  adapting the method of the National Committee for Clinical Laboratory Standards for testing filamentous fungi (M38-P). Amphotericin B and miconazole showed a very good activity against both genera (all isolates were susceptible to both drugs). Ketoconazole, fluconazole and itraconazole showed a better activity against Chrysosporium (all strains were susceptible to ketoconazole and fluconazole and 25%  resistant to itraconazole) than against Scytalidium. 7.69% of the strains of Scytalidium were resistant to ketoconazole, 15.38% were resistant to fluconazole and 62.50% to itraconazole. Flucytosine was more active against Scytalidium (23% of the strains  resistant) than against Chrysosporium (all strains resistant). From in vitro data and the results of some clinical treatments, we conclude that amphotericin B should be the drug used in the treatment of severe infections by Scytalidium and Chrysosporium species.
 
 

PDF file

In: Kushwaha RKS, Guarro J (Eds.). Biology of Dermatophytes and other Keratinophilic Fungi.
Revista Iberoamericana de Micología, Bilbao, 2000.
 
 

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