Model systems for the study of dermatophyte and non-dermatophyte invasion
of human keratin
Malcolm Richardson1 and Michael Edward2
1Mycology Unit, Department of Bacteriology & Immunology,
Haartman Institute, University of Helsinki, Finland;
Both dermatophyte and non-dermatophyte fungi can colonise and invade the
keratin of skin, nail and hair. The fungal morphological forms that adhere
to these keratinaceous substrates are most probably arthroconidia and hyphal
fragments in association with exfoliated corneocytes. Towards a greater
understanding of the ability of fungi to utilise keratin we have developed
a series of experimetal models to stimulate the invasion of the stratum
corneum, the human nail and the hair follicle. In many respects the mode
of invasion mimicked human disease. The models were used to determine the
bioavailability of terbinafine in keratinous substrata. Terbinafine prevented
invasion of keratin by Trichophyton mentagrophytes. These models appear
to be very suitable for the study of the mode of action of antifungal drugs
used in the treatment of dermatomycoses.
2Department of Dermatology, Robertson Building, University of
In: Kushwaha RKS, Guarro J (Eds.). Biology
of Dermatophytes and other Keratinophilic Fungi.
2000-2019@ Revista Iberoamericana de Micología. All rights reserved.
Revista Iberoamericana de Micología, Bilbao, 2000.